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In this paper I formulate a theory which I hope will harmonize a large number of clinical and experimental data, supply an interpretation of certain diseases, and show by what means many diverse causes produce the same end effects.

Even should the theory prove ultimately to be true, it will in the mean time doubtless be subjected to many alterations. The specialized laboratory worker will, at first, fail to see the broader clinical view, and the trained clinician may hesitate to accept the laboratory findings. Our viewpoint has been gained from a consideration of both lines of evidence on rather a large scale.

The responsibility for the kinetic theory is assumed by myself, while the responsibility for the experimental data is shared fully by my associates, Dr. J. B. Austin, Dr. F. W. Hitchings, Dr. H. G. Sloan, and Dr. M. L. Menten.[2]